• Julie Collorafi

Trump Admin Awarded $1.2M Grant to UCSF Mouse Biology Program for Humanized COVID-19 Test Mice

Updated: Nov 17, 2021

The Mouse Biology Program at the University of California at Davis in San Francisco has been the recipient of millions of dollars worth of grants from the federal government and is one of the primary providers of cohorts of humanized mice to researchers through its program as thoroughly documented by CNSNews in this article by Terence P. Jeffrey.

In 2013, UCSF entered a contract worth $13,799,501 with the NIH to provide cohorts of two types of humanized mice with surgically implanted human fetal tissue for HIV research. The contract, “Humanized Mouse Models for HIV Therapeutics Development”, specifically requires the employer to obtain human fetal tissues for the project. It followed up on a similar contract, (“Tissue Based Small Animal Model for HIV Drug Discovery”) starting in 2006 with a net worth of $14,628,247. The 2013 contract had the option for the government to renew the contract for up to six additional one-year periods running through Dec. 5, 2020.

Terence Jeffrey provides a screenshot of the contract showing that it requires that the employee produce a cohort of 50 mice per month of the first model (the SCID-hu Thy/Liv mice per month engrafted with tissue from a single donor) and 40 of the second model (the immunodeficient mice engrafted with human fetal thymus and liver tissue and other cells and/or tissues per month engrafted with tissue from a single donor.) (This would involve, barring failed experiments, from what I can tell, organs from 24 aborted babies per year.)

The Trump Administration famously imposed a ban on fetal research funding in a June 9, 2019 HHS press release, stating that it was ending its contract with the University of California:

Fast forward to August, 2020, when the Mouse Biology Program announced that the NIH had awarded them a $1.2 million grant to produce a cadre of of humanized mice at the University of California-Devis to be supplied to COVID researchers to test the vaccine. The Mouse Biology Program issued a statement:

The National Institutes of Health has awarded a grant of $1.2 million to the Mouse Biology Program at the University of California, Davis, to create mice that are susceptible to the COVID-19 virus, and to distribute them to researchers. The goal is to create mice that can be used to reproduce human COVID-19 disease, said Kent Lloyd, director of the Mouse Biology Program and professor in the Department of Surgery at the UC Davis School of Medicine. (Emphasis added.)

Further details were given on how the mice would be created:

Lloyd’s team plans to create “humanized” laboratory mice by using CRISPR-Cas9 technology to precisely replace the genetic code for the mouse equivalent of ACE2 with the code for human ACE2.

Searching on the NIH Reporter website, I was able to find one of the grants, awarded on June 26, 2020, to the University of California-San Diego, worth $434,000, called "Generating Novel Humanized Mouse Models for in vivo COVID19 Mechanism Studies and Therapeutics Tests."

Screenshot of the details of the grant from the NIH Reporter website:

Screenshot of the project summary:

The specifications given above correspond with the 2019 Wahl et al. study, in that it proposes to "generate two novel humanized mouse models that can be infected by SARS-CoV-2, faithfully mimic the human disease, and be used to test for promising treatments." The mice will be used to test "to test the effectiveness of candidate FDA approved drugs for their effectiveness in halting COVID19 ".

The Mouse Biology Program's press release about the grant stipulated that the mice be susceptible to the COVID-19 virus and that they can be used to reproduce human COVID-19 disease.

This corresponds with the objective of the Wahl et al. study's two precision mice models as described in the Abstract section of the study:

Lung-only mice and bone marrow/liver/thymus-lung humanized mice substantially increase the number of human pathogens that can be studied in vivo, facilitating the in vivo testing of therapeutics.

The only grant I can see on the NIH Reporter website specifically for $1.2 million awarded to the University of California in 2020 is a program at the University of California-Los Angeles entitled, "Clinical evaluation of SARS-CoV-2 subunit vaccine in a Phase I human clinical study."

Screenshot here of the description from the NIH Reporter website:

This $1,225,641 grant was awarded on July 15, 2020.

I have been unable to find any further information on the $1.2 million grant given to the Mouse Biology Program at the University of California-Davis for the creation of cohorts of humanized COVID-19 test mice.

However, the facts remain that a $1.2 million grant was given to the Mouse Biology Program to create two humanized mouse COVID-19 test mice models with the same characteristics demonstrated in Ralph Baric's 2019 UNC Wahl et al. study which produced two highly humanized precision mice models susceptible to COVID-19 which were able to reproduce COVID-19 disease.

Most significantly, the NIAID grant was awarded to a research center that has decades of experience in engineering humanized mice engrafted with human fetal tissue. In particular, as Terence Jeffrey has documented, the second mouse model generated in the last contract with the HHS, matched the characteristics of Ralph Baric's gruesome BLT-L mouse which was humanized by surgically implanting a "sandwich" of human fetal liver and thymus (obtained from Advanced Bioscience Resources) under the renal capsule of the mouse followed by an injection of fetal liver cells into the tail and engrafting fetal lung tissue on the back:

The second mouse model will consist of immunodeficient mice engrafted with human fetal thymus and liver tissue and other cells and/or tissues, such that the model (or mice) has the following characteristics: can be infected by the systemic or mucosal routes, reconstitutes gut-associated and other lymphoid tissues, and develops viremia and disseminated infection in engrafted human tissue. (Emphasis added.)

In conclusion, it would appear that there is a high likelihood that the Trump Administration awarded this grant to the BLT mice experts at the University of California to engineer a continuous supply of the specially designed and highly humanized precision mice models created in the Wahl et al. study.

For more information on the history of horrific humanized mice experiments conducted at UCSF , visit Pro-Life San Francisco's website. CAUTION: extremely disturbing graphic images.

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