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  • Julie Collorafi

Multiple Human Embryonic Stem Cell Lines Used to Humanize COVID-19 Test Mice and to Create Platforms

Human embryonic stem cells (hESCs) are used to humanize mice. They are also used to generate human tissue, organoids and cells for testing platforms. This chart shows examples of each:

HFH4-hACE2

For more information on this model humanized with fetal clone serum and the HEK293 stem cell line, see this article:


Human Embryonic Stem Cells: Catalyst for the Launching of the COVID-19 Pathogen


The Fetal Industry's Essential Connection to COVID-19 Vaccines



B6J.Cg-Tg(FOXJ1-ACE2)1Rba/Mmnc

The NIH-funded Mutant Mouse Resource and Research Center (MMRRC) offers this mouse model humanized with fetal clone serum and the HEK293 stem cell line for COVID-19 research. For more information see this article:


The Fetal Industry's Essential Connection to COVID-19 Vaccines


hESC-CMs (human embryonic stem cell cardiomyctes)

This example is a testing model of beating cardiomycytes (heart muscle cells) derived from human embryonic stem cells, called hESC-CMs. For more information, see this article:


COVID-19 Test Models and Platforms Made with Human Embryonic Stem Cell Lines hESCs)


hPSC-LO (human pluripotent stem cell lung organoid)

A team of researchers from Weill Cornell Medicine and Mount Sinai Hospital developed two novel models of humanized mice using four human embryonic stem cell lines. The first, the hPSC-LO, has human lung organoids.


For more information, see this article:


COVID-19 Test Models and Platforms Made with Human Embryonic Stem Cell Lines hESCs)



hPSC-LO (human pluripotent stem cell colonic organoid)

A team of researchers from Weill Cornell Medicine and Mount Sinai Hospital developed two novel models of humanized mice using four human embryonic stem cell lines. The first, the hPSC-LO, has human lung organoids.


For more information, see this article:


COVID-19 Test Models and Platforms Made with Human Embryonic Stem Cell Lines hESCs)


hPSC-derived Human Organoids

Six human embryonic stem cells lines were used to create functional human cells, tissues, and organoids. In the project, a human liver organoid was engrafted in a immune deficient mouse. The hPSC-derived human organoids can also be used as testing platforms. For more information, see this article:


COVID-19 Test Models and Platforms Made with Human Embryonic Stem Cell Lines hESCs)

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